review questions

• The Rh system genes are: RHD and RHCE.
• D antigen is found in 85% of the Caucasian population and is always significant for transfusion purposes?
• weaker-than-expected reactions with anti-D typing reagents categorized as Weak D
• Cells carrying a weak D antigen require the use of Indirect Antiglobulin Test (IAT) to demonstrate its presence
• Rh antigens are inherited as codominant alleles
• Biochemically speaking, proteins are Rh antigens
• Rh antibodies are primarily of IgG class
• Rh antibodies react best at 37°C
• Rh antibodies have been associated with Hemolytic disease of the fetus and newborn
• Rhnull cells lack Rh antigens
• D- has the strongest expression of D
• An individual has the following serologic reactions: D+C+E+c+e+f-, has R2R2
• Dce is the most common haplotype in the African American population
• If a patient who is R1R1 is transfused with RBCs that are R0r, he most likely to produce Anti-c antibodies