Female Reproductive System & Breast IIa

• Corpus Luteum failure is the main cause of inadequate luteal phase leading to abnormal uterine bleeding
• Endometrial polyps is characterised by the presence of disordered or mildly dilated endometrial glands
• Failure of ovulation is characterised by widely spaced glands with variation in size & shape in the endometrium
• The pathogenesis of abnormal uterine bleeding is ovulatory failure to leading to excess oestrogen relative to progesterone
• Mutations in PTEN is associated with endometrioid carcinomas
• Endometroid Carcinomas make up 80% of endometrial carcinoma cases.
• Leiomyomas have a characteristic whorled cut surface on macroscopic examination
• Serous type carcinomas are characterised by small tufts & papillae