Coagulation factors

• Also known as Factor I

  Fibrinogen
• Also known as Factor II


  Prothrombin
• Also Known as Factor V

  Labile factor
• Also known as Factor VII

  Stable Factor
• Also known as Factor VIII


  Antihemophillic factor
• also known as Factor IX


  Christmas factor
• also known as factor X

  Stuart Prower Factor
• also known as factor XI


  Partial thromboplastin antecedent
• also known as factor XII

  Hageman factor / Glass factor
• also known as factor XIII

  Fibrin Stabilizing factor
• also known as Prekallikrein


  Fletcher factor
• also known as HMWK

  Fitzgerald factor
• functions as thrombin substrate

  Fibrinogen
• activated by thrombin; Va is a cofactor for the activation of prothrombin by Xa


  Labile factor
• activated by thrombin in the presence of Ca


  Stable factor
• activated by thrombin; VIIIa is a cofactor in the activation of X by IXa


  Antihemophillic factor
• activated by XIa in the presence of Ca


  Christmas factor
• Activated in the surface of activated platelets by the tenase complex and VIIa in the presence of TF and Ca

  Stuart Prower Factor
• Activated by Factor XIIa

  Partial Thromboplastin Antecedent
• Binds to exposed collagen at the site of blood vessel injury; activated by HWMK and Kallikrein


  Hageman Factor/ Glass Factor
• Stabilizes fibrin


  Fibrin stabilizing factor
• Activates factor XII


  Prekallikrein
• Cofactor: binds to factor XIIa and Prekallikrein

  Fitzgerald factor
• Common pathway:


  Factors:

  I

  II

  V

  X

  XIII

  Prekallikrein
• Extrinsic pathway factors:


  VII
• Intrinsic coagulation factors


  Factor XI

  Factor XII
• Contact factors:


  Prekallikrein

  HMWK
• Zymogens: proenzymes, enzyme precursors:

  Factor II, VII, IX, X, XI, XII, Prekallikrein
• when zymogens become activated;


  it becomes serine proteases designated by "a"
• Co-factors:


  non-enzymatic V, VIII, HMWK, Tissue factor (Thromboplastin)
• roles include coagulation, activation and fibrinolytic activation:

  Kinin factors: prekallikrein, kallikrein, HMWK
• most labile, consumed in coagulation, found on platelets

  fibrinogen group: I,V,VIII,XIII
• Vitamin K dependent, may be affected by warfarin, diet, antibiotics


  Prothrombin group: II, VII, IX, X
• initiate intrinsic pathway and fibrinolysis

  Contact group: XI, XII, HMWK, Prekallikrein
• proposed to replace the traditional cascade


  cell-based model of coagulation
• more accurately explains coagulation in vivo

  cell based-model coagulation
• cell based model occurs in 3 overlapping stages:

  initiation

  amplification

  propagation
• vascular endothelium and circulating blood cells are disrupted: interaction of FVII with TF

  initiation
• platelets, factors V, VIII, XI are activated by thrombin on the platelet surface


  amplification
• Results in the production of adequate amount of thrombin, production of temporary plug at the site of injury, stops the interruption of blood supply


  Propagation