Increasing in cell sizes results in a decease in the surface area to volume ratio
A reduction in the surface area to volume ratio, results in the cell becoming less efficient at acquiring the nutrients it needs
Inefficient diffusion limitscell size
Large cells compartmentalize their internal environment with organelles. Maximising their ability to undertake different life processes as optimum condition
Organelles create more space for membrane-bound enzymes increasing activity in cells
Size of surface area limits rate of exchange that can occur