Emtricitabine

• What is emtricitabine?

  Nucleoside reverse transcriptase inhibitor
• What are the indications of emtricitabine?

  HIV
• What are the side effects of emtricitabine?

  Diarrhoea

  Vomiting

  Nausea
• What is the pharmacology of emtricitabine?

  Target: Reverse transcriptase

  Activity: Antagonist
• MOA - emtricitabine

  Phosphorylated to emtricitabine 5'-triphosphate (active)

  HIV-1 reverse transcriptase incorporates emtricitabine into forming DNA strands -> new nucleotides unable to incorporated -> viral DNA chain termination -> virus is unable to incorporate its DNA into host DNA & replicate host cell machinery -> reduced viral load