disorders of secondary hemostasis

• No fibrinogen

  Prolonged PT

  Prolonged APTT

  Prolonged TT

  Afibrinogenemia
• afibrinogenemia is characterized by these symtomps (5):

  umbilical stump bleeding

  easy bruising

  ecchymoses

  poor wound healing

  hematuria
• Low Fibrinogen, Prolonged PT, Prolonged APTT, Prolonged TT

  Hypofibrinogenemia
• characterized by mild bleeding

  Hypofibrinogenemia
• Normal fibrinogen antigen with low activity

  Dysfibrinogenemia
• Possible hemorrhage/ Thrombosis, Asymptomatic

  Dysfibrinogenemia
• post operative bleeding

  epistaxis

  menorrhagia

  easy bruising

  Hypoprothrombinemia
• prolonged PT

  prolonged aPTT

  prolonged BT

  Parahemophilia
• Epistaxis

  menorrhagia

  easy bruising


  parahemophilia
• deficiency in factor V

  parahemophilia
• prolonged PT, normal aPTT

  Hypoproconvertinemia
• Epistaxis

  menorrhagia

  cerebral hemorrhage

  Hypoproconvertinemia
• Factor VII disease

  Hypoproconvertinemia
• normal PT, BT and platelet function, prolonged aPTT

  Hemophilia A
• mild, moderate, severe bleeding tendecies

  Hemophilia A

  VWF

  Hemphilia B
• Factor VIII disease

  hemophilia A
• Normal PT, variable aPTT and BT

  vWF
• normal PT, prolonged aPTT

  hemophilia B
• factor IX deficiencies

  hemophilia B
• Prolonged PT and aPTT

  Stuart-Prower Deficiency

  Hemophilia C

  Hageman Trait

  Prekallikrein

  HWMK

  HYPOPROTHROMBINEMIA
• Menorrhagia

  bruising

  epistaxis

  CNS deficiency

  Stuart Prower Deficiency
• factor X deficiency

  Stuart Prower deficiency
• Mild bleeding

  bruising

  epistaxis

  Hemophilia C disease
• Factor XI deficiency

  Hemophilia C
• Factor XII disease

  Hageman trait
• Thrombotic tendency

  no bleeding

  Hageman trait

  Prekallikrein

  HMWK
• Normal PT and PTT

  abnormal 5M urea solubility assay

  Factor XIII deficiency
• Excessive fibrinolysis

  male sterility

  difficulty conceiving

  intracranial hemorrhage


  Factor XIII deficiency