Hematopoiesis

• GPIbα is the receptor for von Willebrand factor (vWF) on platelets.
• vWF normal is platelet count
• TTP differs from DIC in that APTT is normal in TTP but prolonged in DIC
• storage pool adhesion are defects of platelet granules that cause them to stick to the walls of the blood vessel
• Lumi-aggregation measure platelet aggregation and ATP release
• TTP is an autoimmune disease characterized neurological problems, fever, thrombocytopenia, microangiopathic hemolytic anemia and renal failure
• P2Y12 ADP receptor agonist is used to monitor platelet aggregation is Clopidogrel (plavix)
• platelet aggregating agents demonstrates a monophonic aggregation curve when used in optimal concentration is collagen
• APTT is sensitive to a deficiency Factor X
• a prolonged APTT is corrected with factor VIII deficient plasma but NOT with factor IX deficient plasma. Which factor is deficient?

  Factor IX
• What is a characteristics of classic hemophilia A?

  mild to severe bleeding episodes
• PT- prolonged, APTT- prolonged, Decreased-platelet count what is the disorder indicated?

  DIC
• What is the predisposing condition for the development of DIC?

  Adenocarcinoma
• Factor XII deficiency is associated with?

  Increased risk of thrombosis
• normal platelet count, PT and function, prolonged APTT?

  hemophilia A
• most suitable product for treatment factor of VIII deficiency is?

  Factor VIII concentrate
• abnormal platelet aggregation test?

  Afibrinogenemia
• prolonged APTT, Normal PT?

  Hemophilia A
• fibrin monomers increased?


  DIC
• associated with multiple factor deficiencies is?

  severe liver disease
• Normal PT and APTT with poor wound healing?

  Factor XIII or 13
• laboratory test affected by heparin therapy?

  Thrombin time
• drugs inhibit ADP mediated platelet aggregations ?

  prasugrel
• thrombin-thrombomodulin complex for activation of?

  protein C
• drug promotes fibrinolysis?


  urokinase
• abnormalities is consistent with the presence of lupus anticoagulant?

  prolonged APTT/thrombosis
• associated with thrombotic event?


  protein C
• an antithrombin drug causing prolonged TT in patients?

  heparin
• laboratory test helpful in diagnosis of aspirin resistance?

  platelet aggregation
• complications may occur as a result in decreased tissue factor pathway inhibitor (TFPI)?

  increased thrombotic risk
• Factor VIII inhibitor occur in patients with Factor VIII deficiency in what percentage?

  10-20%
• Bethesda assay is used for which determination?

  Factor VIII inhibitor titer
• ecarin clotting time may be used to monitor?

  Hirudin therapy
• Which may interfere with the activated protein C resistance (APCR) screening test?

  Lupus anticoagulant
• thrombophilia associated with?


  hyperfibrinogenemia
• heparin-induced thrombocytopenia (HIT) anticoagulant drugs used?

  lepirudin
• used to monitor LMWH therapy?

  Anti-Xa heparin assay
• preferred method to monitor heparin therapy at the point of care during cardiac surgery?

  Activated clotting time test (ACT)