ACE & ARBs

• CAPTOPRIL (Capoten)
• Lisinopril (Prinivil, Zestril)

  
• Enalapril (Vasotec)

  
• Fosinopril

  
• Benazepril

  
• Quinapril (Accupril)

  
• Ramipril (Altace)

  
• Trandolapril (Mavik)

  
• Losartan

  
• Telmisartan

  
• Irbesartan

  
• Valsartan

  
• Candesartan (Atacand)

  
• Olmesartan (Benicar, Olmetec)

  
• Verapamil

  
• Nifedipine

  
• Deltiazem

  
• CAPTOPRIL (Capoten)

  
• Captopril was discovered?


  1977
• first ACE inhibitor?


  Captopril
• specific competitive inhibitor angiotensin-converting enzyme (ACE)?

  Fosinopril
• is hydrolyzed by esterases to the pharmacologically active form in fosinopril?

  sodium
• decreases levels of angiotensin II leading to less vasoconstriction and decreased blood pressure.


  Enalapril
• What are the 2 active drugs in ACE inhibitors?

  Captopril and Lisinopril
• main uses are in the treatment of ARBSs?

  Hypertension

  diabetic nephropathy

  congestive heart failure

  coronary artery disease

  kidney disease.
• Valsartan(__),

  Olmesartan (__).

  Candesartan (__),

  Irbesartan (__),

  Telmisartan (__),

  Eprosartan (__),

  Losartan (__),

  Azilsartan (__)

  Valsartan(Diovan),

  Olmesartan (Benicar).

  Candesartan (Atacand),

  Irbesartan (Avapro),

  Telmisartan (Micardis),

  Eprosartan (Teveten),

  Losartan (Cozaar), and

  Azilsartan (Edarbi)
• new anti-hypertensive drug with the same mechanism of losartan?

  Valsartan
• calcium antagonists?


  Calcium Channel Blocker
• treat angina by reducing myocardial and oxygen demand and reverse coronary vasospasm?

  Phenylakylamines (Verapamil)
• most common smooth muscle selective class, reduce systemic vascular resistance and arterial pressure?

  1,4-Dihydropyridines (Nifedipine)
• - have both cardio-depressant and vasodilatory effect?

  Benzothiazepines (Deltiazem)
• CCBs treat?

  Angina (chest pain)

  Hypertension (high bp)

  Tachyarrythmia (rapid irregular heart beat)