breakthroughs of painkillers, like nitrous oxide, ether, chloroform
these reduced pain but didn't stop infection, surgery only became safe when antiseptics were introduced
Theory of Spontaneous Generation
that living organisms could mysteriously appear from non-living substances
improvements in tech meant scientists could see microbes of living matter
Germ Theory
Pasteur proved germs caused disease
used swan necked flasks - when neck was unbroken germs couldn't get in, so no decay vs neck being broken meant germs entered so milk went sour. observed over weeks to prove that germs couldn't spontaneously appear
published in 1861
Germ Theory - Koch
1876
noticed that animals in certain areas developed anthrax
gathered blood samples and used a chemical that stained bacteria
discovered bacteria only present in diseased animals
he cultivated bacteria and injected it into healthy proving it caused disease then reisolated bacteria
Koch's Postulates, linking a specific microorganism to disease