Part 2 pharm

• Antiprozoa

  Metronidazole ?

  giardia

  neurotoxicity and not use in livestock
• Tinidazole ?

  giardia and tritrichomonas in cats
• Ronidazole ?

  Pigeon -trichomonas, histomonas meleagridis,

  dogs - Giardia
• Benznidazole?

  trypansoma Cruzi - dogs

  adverse - carcinogenic, mutagenic, teratogenic
• Nifurtimox ?

  Trypanosoma cruzi , chagos in dogs

  mutagenic and carcinogenic
• Paromomycin ?

  Giardia - cat

  leishmania - dog

  entamoeba

  cryptosporidium - cattle, goat, cat

  tritrichomonas foetus- cat
• Albendazole ?

  treat Giardia

  dog and cat - myelosupression , not used in cats , teratogenic
• Fenbendazole ?

  giardia - dog, cats, cattle

  safer
• Doxycycline ?

  babesia canis - dogs
• Oxytetracycline?

  babesia, anaplasma, theileria

  vomiting, imbalance flora, acute cardiac toxicity calves
• Clindamycin?

  toxoplasma gondii

  neospora

  hindlimb function doesn’t return to normal
• Trifluridine ?

  treat herpes keratitis - cat and horse

  adverse - discomfort , palpebral oedema
• Vidarabine ?

  ocular herpes infection

  with acyclovir resistance strains

  adverse - GI upset and CNS
• Acyclovir ?

  treat herpes

  neonatal herpes

  no vet use

  adverse - GI upsets , renal insufficiency, CNS

  doesn’t treat latent infections
• Valacyclovir ?

  treat herpes

  adult horses

  oral or IV

  adverse - GI upsets , renal insufficiency, CNS effects
• Ribavirin?

  toxic and limited use

  treat felv, fiv, calicivirus, coronavirus - cat

  distemper and parainfluenza - dog

  adverse - GI upset, bone marrow toxicity,

  gi upset, hepatotoxicity, haemolytic anemia
• Remdesivir ?

  broad spectrum

  treat feline infections peronitis
• Zidovudine ?

  treat fiv, bovine leukemia, feline leukemia

  adverse- cat dose dependent progressive anemia, neutropenia, granulocytopenia
• Amantidine ?

  narrow range

  treat pain

  myxoviruses, paramyxoviruses , toga virus, influenza a

  adverse - horse fatal seizure
• Rimantidine ?

  influenza virus infections horses

  treat pain
• Interferons - cat, dog, cattle, pig, horses - herpes, calicivirus, stress induced respiratory and intestinal disease

  dogs and cats - parvo, fiv, feline leukemia

  adverse - intranasal and parenteral - hyperthermia, anorexia, malaise
• Allylamines - terbinafine ?

  dermatophytosis - dog and cat

  microsporum canis , malassezia derm.

  adverse - liver , inhibit cyto p450

  cats facial dermatitis, pruritus
• Nystatin ?

  local and systemic

  dermatophytosis , candida albacan - turkey
• Natamycin ?

  ocular solutions for keratomycosis
• Amphotercin B ?

  severe systemic fungal infections

  pulmonary aspergillosis

  adverse - nephrotoxic , phlebitis , nausea , vomiting, cardiac arrhythmias
• Griseofulvine ?

  microsporum, trichophyton, epidermophyton

  distribute hair, skin, nails

  cats - leukopenia, anemia, hepatic activity, neurotoxicosis

  teratogenic , horse bad liver
• Ketoconazole and itraconazole - need acidic ph

  ketoconazole, fluconazole, itraconazole - topical and systemic

  candida, aspergillosis, crytococcosus, malassezia
• Miconazole, enilconazole, clortrimazole ?

  dermatophyte and filamentous fungi, nasal aspergillosis, otitis externa
• Fipronil ?

  adult fleas , ticks, biting lice

  Does not prevent fleas from biting and feeding

  adverse - hyperactivity, hyperexcitability, convulsions, not young animals
• Imidacloprid ?

  adult and larval fleas - dogs and cats

  prevent fleas from biting

  topically

  combo with permethrin - kill mosquitos and ticks
• Nitenpyram ?

  orally - cats and dogs

  fleas resistance to fipronil

  adverse - nictonic effects and hepatic failure

  not cats and dogs -younger than 4 months
• Afoxolaner, fluralaner , lotilaner, sarolaner?

  topically,

  treat and prevent fleas , control ticks , demodicosis, sarcoptes, notoedies, otodectes

  fleas, ticks, mites
• Insects growth inhibitors

  s-methopiene and pyriproxifen?

  fleas - cats and dogs
• Insects development inhibitors

  lufenuron and diflubenzuron?

  lufenuron - fleas

  diflubenzuron - fly/ grasshopper
• Macrocyclic lactoses?

  mites, lice , flies, ticks, inhibit larval development

  eprinomectin and moxidectin
• Organophosphate and carbamates ?

  toxicity

  not commonly used

  adverse - Sludd
• Amitraz ?

  lice, ticks, mites , treat demodicosis

  adverse - sedation, colon obstruction, horses

  not use on chihuahuas
• Piperonly butoxide - help enhance insecticides
• Repellents ?

  diethyl - m - toluamide (deet)
• Albendazole - nematode drugs?

  broad spectrum

  all GI nematodes

  tapeworms

  adult liver flukes

  lungworms

  suppress cyst excretion of Giardia