inhibitors

• Inhibitors​ ​are substances which stop the enzyme from binding to its substrate. They can therefore control the progress of a reaction
• Types of inhibition:

  • Competitive inhibition
  • Non-competitive inhibition
  • Feedback inhibition​
  • Reversible inhibition
• Competitive inhibition


  This is when an inhibitor molecule binds to the active site of the enzyme and stops the substrate from binding to it; it can be reversed by increasing the substrate concentration as the inhibitor is diluted
• Non-competitive inhibition


  An inhibitor doesn’t bind to the active site but binds to a different part of the enzyme which changes the shape of the enzyme; it decreases the reaction rate as the substrate cannot bind to the enzyme
• Feedback inhibition


  This occurs when the end product binds to the enzyme at the start of the reaction/pathway and this stops the pathway until the concentration of the end product decreases
• Reversible inhibition


  They can be competitive or non-competitive. Once they are removed from the enzyme, inhibition stops and it can work again