SP 128: Pharmacology

Created by

Amanda

Cards (21)

As SPs, interventions we offer to patients can be through behavioral or pharmacological
medication history may explain changes in mental status or communication skills
Pharmacology: the study of substances that interact with living systems through chemical processes
Medical Pharmacology: the science of substances used to prevent, diagnose, and treat disease
Toxicology: Branch of pharmacology dealing with undesirable effect of chemicals
Drugs
substances that brings biological change through chemical process
Properties of Drugs
Forms
Molecular Size/Weight
Shape
Chemical bond
Pharmacokinetics
what the body does to the drug
Absorption: get in
Distribution: will go
Metabolism: broken down
Excretion: leave
Pharmacodynamics
what the drugs does to the body
enantiomeric pair: drugs that have the same exact chemical composition but the molecules are arranged somewhat differently
Drug interact with receptor through its chemical bond
Covalent Bond
Strongest, Irreversible
Share Electrons
Aspirin: Enzyme Receptor in platelets
Electrostatic/Ionic
weaker, most common
electron of one molecule is transferred to another
the net negative and positive charges act like a magnet
Hydrophobic
weakest, used for lipid-soluble drugs
two hydrophobe molecules coming together to avoid water molecules
cross barriers that hydrophilic drugs cannot do
Absorption: drug getting into systematic circulation
Drugs administered into two ways
Intravenous: 100% goes into the main bloodstream
Taken Orally: must go through gut; 50% bioavailability
Pathway of a drug taken orally
Oral Intake
Stomach
Intestines
Portal Circulation
Liver
Systemic Circulation
Stomach is acidic while the intestine is alkaline
Drugs don't initiate metabolic process in the body but they alter biochemical process
Agonist: activates receptor
Antagonist: inhibits receptor
Therapeutic Index: Important measure of the safety of a drug