Tolerance

• Tolerance

  -after chronic exposure to a drug or behaviour the body adapts which means the initial dosage doesn't have same effect anymore.

  -This means a higher dosage needs to be taken to get that same initial feeling.
• Metabolic tolerance

  -body metabolises substance quicker so substance leaves body quicker which means higher dosage needed.
• Cellular tolerance

  -change in responsiveness to neurons in the brain for higher levels so higher dosage needed for same effect.
• Cross tolerance

  -tolerance of the drug reduces sensitivity to other drugs.