Skin Pathology Ib

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Created by
Dara Adu

Cards (13)

  • SCC is associated with mutations in TP53, HRAS & Notch receptors
  • The defining features of Melanocytic Naevus are junctional, intradermal & compound components
  • The characteristic clinical presentation of melanoma is rapid enlargement and irregular borders
  • Seborrheic keratosis have a Stuck on appearance , pseudocysts , horn cysts
  • Basal cell carcinoma have Palisading nuclei
  • Squamous cell carcinoma have Keratin pearls
  • Actinic keratosis are Sand paper like to touch
  • Melanoma has Cherry red nuclei
  • A microscopic finding characteristic of Dysplastic Naevus is compound naevi with abnormal fusion of navus cell nests
  • Actinic Keratosis typically shows cytologic atypia in the lower portions of the epidermis
  • BCC is due to dysregulation of Hedgehog pathway
  • Melanocytic proliferations are due to BRAF activating mutations but melanomas also have NRAS & c-KIT receptor tyrosine kinase
  • Congenital naevi have adenexal involvement and occur with neuro - cutaneous melanosis