A.P reaches synaptic knob
VG Ca2+ channels open
Ca+ flood pre-synaptic knob
Causes vesicles to fuse with pre-synaptic membrane
Release NT into synaptic cleft (exocytosis)
NT diffuse across synaptic cleft
Binds to receptors on post-synaptic membrane
If threshold potential is reached
VG Na+ channels open
Na+ enter post-synaptic neuorone
Depolarisation occurs
A.P is generated at post-synaptic neurone
