Parkinsons

• what happens in Parkinsons? (copy+paste)

  • less dopamine NT released into synaptic cleft
  • via exocytosis
  • less dopamine binds to receptors on post-synaptic neurone
  • less Na+ channels open
  • less likely A.P generated in post-synaptic neurone
• L Dopa

  • turned into dopamine
  • in brain
  • (WE CANT GIVE DOPAMINE DIRECTLY
  • dopamine cant cross blood-brain barrier)
  • increases dopamine levels in brain
  • A.P generated in post-synaptic neurone
  • reduces symptoms of parkinsons