Depression

• how does depression happen?

  • less serotonin NT released into synaptic cleft
  • via exocytosis
  • less serotonin binds to receptors on post-synaptic neurone
  • less Na+ channels open
  • less likely A.P is generated in post-synaptic neurone
• MDMA treatement

  • MDMA binds to reuptake proteins in pre-synaptic neurone
  • Blocks them
  • increases levels of serotonin in synaptic cleft
  • more serotonin available to bind to receptor on post-synaptic neurone
  • generates AP in post-synaptic neurone
  • Needs more MDMA to keep AP being generated