Aspergillus spp

• What is the morphology of Aspergillus?

  Gram positive with acute angle branching
• What type of environments does Aspergillus grow in?

  High osmotic pressure and nutrient-depleted
• What are the main pathogens in the genus Aspergillus?

  Aspergillus Fumigatus and Aspergillus Flavus
• What are aflatoxins associated with?

  Carcinogenic effects and hepatocellular carcinoma
• What is allergic bronchopulmonary aspergillosis (ABPA)?

  Type 1 hypersensitivity with increased IgE
• What is pulmonary aspergilloma?

  Fungus balls in the lungs
• What is angioinvasive aspergillosis?

  Invasion of blood vessels with rapid dissemination
• What are symptoms of angioinvasive aspergillosis?

  Fever, cough, and hemoptysis
• What is the treatment for ABPA?

  Oral prednisone for severe cases
• What is the treatment for pulmonary aspergillomas?

  Surgical debridement and lobectomy
• What is the treatment for angioinvasive aspergillosis?

  Amphotericin B and IV voriconazole
• What are the clinical manifestations of aspergillosis?

  • Allergic bronchopulmonary aspergillosis (ABPA)
  • Pulmonary aspergilloma
  • Angioinvasive aspergillosis
• What are the microbiological diagnosis methods for Aspergillus?

  • Gram staining
  • Ziehl-Neelsen staining
  • Culture on Sabouraud’s agar