Adrenergic Receptors

• Blood vessels: Vasoconstriction - alpha 1
• Radial smooth muscle: Mydriasis - alpha 1
• Increased closure of internal sphincter of the bladder alpha 1
• Contraction of prostate gland - alpha 1
• piloerection (goosebumps) - alpha 1
• Once activated, the effect is AUTOREGULATION - alpha 2
• heart: beta 1
• kidney: beta 1
• increased chronotropy & intropy: beta 1
• increased AV-node conduction velocity - beta 1
• increased renin release - beta 1
• lungs & uterus - beta 2
• bronchodilation: beta 2
• tocolysis: beta 2
• uterine relaxation: beta 2
• isoxsuprine: drug for uterine muscle relaxation
• can be found in neuromuscular end plates in the skeletal muscle: beta 2
• adipocytes: beta 3
• lipolysis: beta 3
• increases ac: d1
• decreases ac: d2
• in smooth muscles: d1
• in nerve endings: d2
• dilates renal blood vessels: d1
• modulates transmitter release: d2
• GI tract glands - M1
• SA, AV nodes ONLY (atrium) not ventricles - M2
• Exocrine glands - M3
• Smooth muscles (Gq) - M3
• Blood vessels - M3
• Increase secretion of HCl - M1
• Decrease HR, conduction velocity = BRADYCARDIA - M2
• Salivation, sweating and lacrimation - M3
• Miosis, bronchoconstriction, bowel movement, urination - M3
• Vasodilation - M3
• Adrenal medulla - NN
• Epinephrine and some Norepinephrine secretion - NN
• Autonomic ganglion - NN
• Stimulation of the postganglionic neuron of both the parasympathetic and sympathetic nervous system - NN
• Neuromuscular junction/ endplates - NM