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DNA Replication
Metabolic Control
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Created by
Kallie Damianakos
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Cards (12)
Metabolic Control
Regulating
the
amount
of
product
in a
biochemical reaction
within a
cell
Levels of Metabolic Control
Protein activity
: Alter protein/enzyme function
Gene Expression
: Alter the rate of reaction in any of the biochemical processes in protein synthesis
Examples of processes in protein synthesis
Transcription
Post-transcriptional modification
Translation
Post-translational modifications
Enzyme Regulation
Inhibitors
,
allosteric regulators
,
cooperativity
Feedback inhibition
Why enzyme regulation occurs
Example:
Tryptophan
Biosynthesis
No
tryptophan
present, needs to
synthesize
Tryptophan present, does not need to
synthesize
Feedback inhibition
on the production of
trp
Regulating
Enzyme Activity
Adjust
activity
of enzymes already present
Short
term,
quick
onset regulation
Gene Expression
What
defines
a
gene
The
product
of
expression
Regulating
Gene Expression
1. The expression of a gene is measured by the amount of
protein products
form
2. The control of gene expression can involve
altering
the
rate
of processes involved in
protein synthesis
Watch the video and record ways in which a
cell controls
the
expression
of a
gene
Two Major Areas for Regulating Gene Expression
Transcription
: affects whether
RNAP
can bind to
transcribe
the gene
Chromosome structure
: how
unwound
the chromosome is affects the ability for the information to be
read
Control
at
Transcription Level
Control the
expression
of
genes
which affects
number
of
enzymes
produced
Long
term,
slow
onset regulation