Metabolic Control

Cards (12)

  • Metabolic Control
    Regulating the amount of product in a biochemical reaction within a cell
  • Levels of Metabolic Control
    • Protein activity: Alter protein/enzyme function
    • Gene Expression: Alter the rate of reaction in any of the biochemical processes in protein synthesis
  • Examples of processes in protein synthesis
    • Transcription
    • Post-transcriptional modification
    • Translation
    • Post-translational modifications
  • Enzyme Regulation
    Inhibitors, allosteric regulators, cooperativity
  • Feedback inhibition
    Why enzyme regulation occurs
  • Example: Tryptophan Biosynthesis

    • No tryptophan present, needs to synthesize
    • Tryptophan present, does not need to synthesize
    • Feedback inhibition on the production of trp
  • Regulating Enzyme Activity

    • Adjust activity of enzymes already present
    • Short term, quick onset regulation
  • Gene Expression
    • What defines a gene
    • The product of expression
  • Regulating Gene Expression
    1. The expression of a gene is measured by the amount of protein products form
    2. The control of gene expression can involve altering the rate of processes involved in protein synthesis
  • Watch the video and record ways in which a cell controls the expression of a gene
  • Two Major Areas for Regulating Gene Expression
    • Transcription: affects whether RNAP can bind to transcribe the gene
    • Chromosome structure: how unwound the chromosome is affects the ability for the information to be read
  • Control at Transcription Level
    • Control the expression of genes which affects number of enzymes produced
    • Long term, slow onset regulation