· timing of hormone release and the levels of hormone release are both critical for normal functioning , if the release hormones is too much or too little at the wrong time it can result in dysfunction bodily systems , for example if levels of cortisol are too high it can lead to cushing’s syndrome which causes high blood pressure and depression – and the most coon cause of excess cortisol is a tumour in the pituitary gland which makes too much of a hormone called adrenocorticotrophic hormone which stimulates the adrenal glands to make too much cortisol.