Effect of loading

• Adaptation - Effect of loading:

  • What is load?
  • An optimal, above average stimulus to the tissue, applied with regularity and of enough duration
  • Dynamic better than static for effecting change
• Adaptation - Effects of loading:

  • Increased cellular activity – promotion of growth factors, activation of dormant cells
  • Promotes an acute inflammatory response – cascade for adaptation
  • Matrix adaptation – increased collagen synthesis, cross-links
  • Increased cross-sectional area
  • Increased stiffness
• Adaptation - Effects of loading - Increased cellular activity:

  • promotion of growth factors
  • activation of dormant cells
• Adaptation - Effects of loading:

  • Promotes an acute inflammatory response -> cascade for adaptation
• Adaptation - Effects of loading - Matrix adaptation:

  • increase in collagen synthesis, cross-links
• Adaptation - Effects of loading:

  • Increase in cross-sectional area
• Adaptation - Effects of loading:

  • Increase in stiffness