antibody stuff, antigen prevalence, enzymes

• HDFN antibodies only

  Sciana, anti-Ge3, Dia
• HDFN and HTR

  Kidd, Duffy, Kell, Colton, Wra
• HTR only

  Yta, Dombrock, Lutheran
• delayed HTR

  Dia and Dib
• Jk(a+b-)

  blacks 51.1%
• Jk(a+b+)

  whites 50% asians 50%
• lutheran antigens are destroyed by trypsin
• lutheran b antibodies react at AHG, IS, or 37 degrees
• Duffy system is encoded by ACKR1
• Fy(a+b+)

  whites 48% and blacks 3%
• Duffy antibodies react optimally at

  AHG phase
• Kell bodies are destroyed by dithiothreitol
• Dia is common in mongolians
• anti-Dia causes HDFN and delayed HTRs
• antigens of the diego system are not affected by enzymes
• anti-Dia causes HDFN and delayed HTRs
• antigens of the diego system are not affected by enzymes
• Dib and Wrb are high incident antigens
• Dia and Wra are low incident antigens
• anti-Wra can cause HDFN and HTRs
• Ytb is prevalent in israeli's
• Ytb enzymes are destroyed by ficin, papain, a-chymotrypsin, but unaffected by trypsin
• Yta is involved in delayed HTRs
• Xg is destroyed by enzymes
• Dombrock antibodies cause HTRs
• Colton antigens are resistant to enzymes
• LWa is a high incident antigen
• LWb is a low incident antigen
• LW antigens are unaffected by enzymes
• LW antigens are destroyed by pronase, disulfide reducing agents
• warm autoantibodies accompany WAIHA, systemic lupus erythematosus, multiple myeloma, CLL, lymphoma
• intravenous RhIG is used to treat immune thrombocytopenia
• intravenous immunoglobulin and Rh immune globulin is used for antenatal and postnatal patients
• dosage: MNS, Rh, Duffy, Kidd
• enzymes destroy M, N, Fya, Fyb, Xga
• enzymes enhance Rh, I, P, Kidd, Lewis
• Rt or below antibodies: M, N, P1, Lea, Leb, A1
• the most clinically significant alloantibodies that are most commonly encountered are D, E, K, Fya
• IHTR antibodies are most commonly A, Kell, Jka, Fya
• DHTR antibodies are most commonly Jka, E, D, C, K, Fya, M