French invasions of Italy
1. Began in 1494 ("First Italian War")
2. When Florence attempted to appease France during its invasion in 1494, it led to the overthrow of the Medici family
3. Italy became a battleground in a series of power struggles between Spain and France
4. Sack of Rome in 1527 by the armies of Holy Roman Emperor Charles V symbolized the end of the Renaissance in Italy