initial dopamine hypothesis = positive symptoms die to high levels of dopamine = as it was found with amphetamine = indirectly increased dopamine and caused positive symptoms = dopamine has a role in attention and perception which can lead to hallucinations and delusions
revised dopamine hypothesis = 5 dopamine subtypes in different areas D1-D5 = antagonist antipsychotics block d2 receptors to reduce positive symptoms
mesolimbic = carries dopamine from VTA to nucleus accumbens where D2 receptors are = overstimulation causes positive symptoms like hallucination and delusions
mesocortical = carry dopamine from VTA to pre frontal cortex where D1 receptors are = too little dopamine here = negative symptoms as pre frontal cortex is linked to emotional responses (affective flattening/avolition) moving (catatonic movement) and cognition (alogia)
