Asexual reproduction can happen in some plants, where a single seed gets blown into a new habitat and then reproduces asexually to cover the whole area
If a new disease comes along and one of the asexual offspring is susceptible, then chances are that all of them will be susceptible and it could wipe out the whole population
Asexual reproduction means the organisms will have less chance of adapting to new conditions like changes in the climate or the introduction of a new competitor
In the short term, the genetic variation from sexual reproduction means the population is less likely to get wiped out by a single event like a new disease, because some individuals will be more resistant to it than others
In the longer term, the genetic variation from sexual reproduction allows for evolution to take place, as the most favorable traits are most likely to be passed on each generation