A limitation is culture bias
Some symptoms of schizophrenia, particularly hearing voices, have different meanings in different cultures.
in Haiti some people believe that voices actually are communications from ancestors.
British people of African-Caribbean origin are up to nine times as likely to receive a diagnosis as white British people, although people living in African- Caribbean countries are not, ruling out a genetic vulnerability.
This means that British African-Caribbean people may be discriminated against by a culturally-biased diagnostic system.