Hematology 1

• Hematology deals with blood
• Blood

  • blood plasma and blood corpuscles
• Total circulating blood volume is 8% of the total body weight
• Buffy coat

  • white blood cells
  • platelets
• Blood plasma

  • yellowish part of the blood
  • 90% water
  • 10% dissolved substances
• Blood corpuscles

  • RBC
  • WBC
  • Blood platelets
• RBC (Erythrocyte)

  • Biconcave
  • no nucleus
  • 120 days life span
  • Delivers oxygen and nutrients to eliminate CO2
  • contains hemoglobin
• Erythropoiesis

  • Production of blood in the bone marrow
• WBC (Leukocytes)

  • defense mechanism of the body
  • 700RBC: 1 WBC
• Granulocytes

  • cytoplasmic granules
  • basophils
  • Eosinophils
  • Neutrophils
• Agranulocytes

  • no cytoplasmic granules
  • lymphocytes
  • Monocytes
• Blood platelets (Thrombocytes)

  • Hemostasis
  • contribute in Clotting
• Megakaryocyte

  • where platelets came from
• osmotic fragility

  • blood’s resistance to hemolysis
• Hemolysis

  • bursting of RBC
  • resulting in release of Hb
• Heredity spherocytosis

  • fragile RBC
• Increased osmotic fragility

  • hereditary spherocytosis
• Decreased osmotic fragility

  • sickle cell anemia
  • iron deficiency anemia
  • thalessmia
• Type A

  • Antigen A
  • Antibody B
  • cant have blood type B or AB
  • can have A or O
• Type B

  • antigen B
  • Antibody A
  • cant have A or AB
  • can have B or O
• Type AB

  • Antigen AB
  • no antibody
  • can have any blood type
  • universal recipient
• Type O

  • neither A or B
  • A and B Antibody
  • can only have O
  • universal donor