non odonto p2

• Normal medullary bone replaced by an abnormal fibrous CT proliferation?

  Fibrous dysplasia
• Dysplastic growth from derange mesenchymal cell activity or a defect in control of bone cell activity?

  Fibrous dysplasia
• Affect proliferation and differentiation of fibroblasts and osteoblasts that make up this lesion?

  Fibrous dysplasia
• Asymptomatic • Enlargement of involved bone • Single or several bone involvement


  fibrous dysplasia
• more common? mono or polyo?

  mono
• (one bone)

  Monostatic Fibrous Dysplasia
• (more than one bone)

  Polyostotic Fibrous Dysplasia
• is common, other bones:

  Jaw involvement, ribs and femur
• involves several adjacent bone

  Craniofacial Fibrous Dysplasia:
• may be initial presenting symptom of craniofacial FD

  facial asymmetry
• Slow progressive enlargement of jaw: painless, unilateral swelling


  Craniofacial fibrous dysplasia
• most common site of craniofacial fibrous dysplasia?

  md: body of md
• Mono?


  equal gender distribution
• Polyo?

  F > M
• McCune-Albright Syndrome Consists of?

  polyostotic fibrous dysplasia, - cutaneous melanotic pigmentation (café-au-lait macules) and o endocrine abnormalities (most common:
• endocrine abnormalities most common?

  precocious sexual development in girls
• diseases in Mccune albright syndrome?

  Acromegaly, hyperthyroidism, hyperparathyroidism, hyperprolactinemia
• Multiple bone lesions of fibrous dysplasia and skin pigmentations

  Jaffe-Lichtenstein Syndrome
• “Ground glass” or “peau d’ orange” effect (not pathognomonic)


  fibrous dysplasia
• fibrous dysplasia, radiopaque or radiolucent?

  both
• Fingerprint bone patern

  fibrous dysplasia
• Poorly defined radiographic and clinical margins of lesions

  FIBROUS DYSPLAIS
• Blends in surrounding bone without evidence of a circumscribed border

  FIBROUS DYSPLASIA
• SHAPE OF RADIOGRAPH OF FIBROUS DYSPLASIA

  epileptic rather than spheric
• Slightly to moderately cellular fibrous CT stroma that contains foci of irregularly shaped trabeculae of immature bone

  fibrous dysplasia
• chinese character

  fibrous dysplasia
• Small lesions tx for FD?

  no tx only biopsy
• Large lesions of FD

  surgical recontouring, deferred until stabilization of disease process
• are impractical since it is relatively large and poorly delineated


  En bloc resection
• improve symptoms of pain and bone density

  Bisphosphonates:
• Malignant transformation is rare, usually in polyostotic type
• Benign neoplasms of undetermined cause • Maybe confused with osteosarcoma microscopically

  OSTEOBLASTOMA and OSTEOID OSTEOMA
• smaller version of osteoblastoma

  Osteoid osteoma:
• lesions larger than 1.5cm in diameter

  Osteoblastoma
• less than 1.5cm

  Osteoid osteoma
• where does osteoid osteoma and osteoblastoma occur?

  vertebrae or long bones
• osteoid osteoma and osteoblastoma less common in?


  craniofacial bones
• osteoid osteoma and osteoblastoma occurs where in mouth?

  Posterior tooth-bearing areas of maxilla and mandible
• Bony cortices may be expanded and tender to palpation


  osteoid osteoma or osteoblastoma
• SEVERE PAIN in

  osteoid osteoma