signs and symptoms of a transfusion reaction include a fever (>1 degree C rise); chills; respiratory distress; hyper/hypotension; abdominal, chest, flank, or back pain; pain at the infusion site; skin manifestations, including rash, flushing, urticaria, pruritis, edema; jaundice/hemoglobinuria; nausea/vomiting; abnormal bleeding; oliguria/anuria