QC2C

• USP chapter of powder flow

  1174
• • frictional forces in a loose powder
  • maximum angle possible

  angle of repose
• it is considered as excellent in flow properties

  25-30
• to improve flow property, we should add _ to have a smooth flow

  glidants
• example of glidants

  talc and silicon dioxide
• it prevents sticking

  lubricant
• example of lubricant

  magnesium stearate
• other names for compressibility index

  hausner ratio or carr's index
• it measures both bulk volume and the tapped volume of a powder

  compressibility index
• it is considered as excellent in the scale of flowability

  <10 or 1.00-1.11
• flow rate through an orifice is also known as

  modified angle of repose
• • useful only with free flowing materials

  flow rate through an orifice
• flow rate through an orifice measures the mass flow rate or volume flow rate through?

  cylinders, funnels, hopper
• parameters that can be obtained:

  • shear stress-shear strain relationship
  • angle of internal friction
  • confined yield strength
  • tensile strength
  • flow factor and other flowability indices

  shear cell
• 3 types of shear cell

  cylindrical, annular, plate-type
• uses microscope

  optical microscopy
• USP chapter of optical microscopy

  776
• series of standard sieves calibrated by national bureau of standardization

  sieving
• USP chapter of sieving

  786
• scattering pattern

  light diffraction measurements
• USP chapter of light diffraction measurement

  429
• equipment used for thickness

  caliper
• the resistance of tablets to problems such as chipping, abrasions, or breakage depends on their hardness

  tablet breaking force
• tablet breaking force is also known as

  tablet hardness
• USP chapter of tablet breaking force

  1217
• instruments used for tablet breaking force

  monsanto, pfizer, erweka
• tablet hardness acceptable force for ordinary compressed tablet

  4-10 kg
• tablet hardness acceptable force for sublingual and chewable

  2
• tablet hardness acceptable force for buccal

  10 kg
• ability of tablet to withstand abrasion

  tablet friability
• USP chapter of tablet friability

  1216
• equipment used for tablet friability

  friabilator
• setting for friabilator

  25rpm
• time setting for friabilator

  4 minutes
• in tablet friability, a weight loss of NMT _ is acceptable. if failed, the test should be repeated _ and the mean of the three tests determined

  1.0% and twice
• the state at which any residue of the unit, except fragments of a soft mass having no palpably firm core

  complete disintegration
• USP chapter of disintegration test

  701
• consist of six open-ended transparent tubes

  basket-rack assembly
• in basket-rack assembly, tubes are held in a _ position by two plastic plates each about 88 to 9 mm in diameter and 5 to 8.5 mm in thickness

  vertical
• in basket-rack assembly, what is attached under the lower plate?

  mesh screen