IS-chap 15 autoimmunity

• Addison's disease


  • Adrenal glands
• Autoimmune hemolytic anemia


  • Red blood cells (RBCs)
• Autoimmune hepatitis (AH)


  • Liver
• Autoimmune thrombocytopenic purpura


  • Platelets
• Celiac disease


  • Small intestine and other organs
• Anti-glomerular besement membrane disease (Goodpasture's syndrome)

  • Kidneys, lungs
• Graves' disease


  • Thyroid gland
• Hashimoto's thyroiditis

  • Thyroid gland
• Multiple sclerosis


  • Myclin sheath of nerves
• Myasthenia gravis


  • Nerve-muscle synapses
• Pernicious anemia


  • Stomach
• Poststreptococcal glomerulonephritis


  • Kidneys
• Primary biliary cholangitis


  • Intrahepatic bile ducts
• Rheumatic fever


  • Heart
• Type 1 diabetes molitus

  • Pancreas
• Addison‘s disease 


  Antibody to adrenal cells
• autoimmune hemolytic anemia 


  antibody to rbcs
• autoimmune hepatitis (AIH) 1

  • smooth muscle antibodies
  • ANAs
• AIH 2

  • Anti-liver kidney microsomal antibody (anti-LKM-1)
  • Anti-liver cytosol type 1 ab (anti-LC-1)
• autoimmune thrombocytopenic purpura 


  anti-platelet antibody
• AGBMD (goodpasture‘s syndrome) 


  Antibody to an antigen in the renal and pulmonary basement membranes
• grave’s disease

  Thyroid-stimulating hormone receptor antibodies (TRAbs)

  Anti-thyroglobulin

  Anti-thyroid peroxidase (TPO)
• Hashimoto’s thyroiditis

  Anti-thyroglobulin

  Anti-thyroid peroxidase (TPO)
• multiple sclerosis


  antibodies to myelin basic proteins
• myasthenia gravis

  Antibodies to acetylcholine receptors

  (AChR)

  Anti-muscle-specific kinase (MuSK)

  Antibody to the lipoprotein LRP4
• pernicious anemia

  • parietal cell antibody
  • intrinsic factor antibody
• poststreptoccocal glomerulonephritis 


  streptoccocal antibodies that cross-react with kidney tissue
• primary biliary cholangitis 


  anti-mitochondrial antibodies (AMA)
• rheumatic fever 


  streptoccocal antibodies that cross-react with cardiac tissue (myosin)