pathological conditions associated with elevation

• Significance of elevated CK-BB may indicate CNS damage/disease, including CVA's, CNS trauma, childbirth, CNS tumors
• pathological increases of CK-MM: MI, muscular dystrophy, muscle damage, hypothyroidism
• CK-Mt has been detected in some cases in malignant tumors and cardiac abnormalities
• type 2 macro-Ck elevation indicates malignancies or liver disease; generally associated with a poor prognosis
• lactate dehydrogenase is elevated in pernicious anemia, hemolytic disorders, liver disorders, AMI
• AST is increased in ulmonary embolism (PE), liver disease, muscular dystrophy, inflammation, MI
• elevation of alkaline phosphatase may indicate hepatobiliary disorders, bone disorders, sometimes elevated in liver disorders and in issues with gallbladder and bile duct
• • GGT diagnostic significance - Increased in hepatobiliary disorders and certain therapeutic drugs (coumadin, phenolbarb, dilantin), pancreatitis, DM, MI (not good diagnostic tool for MI)
• amylase diagnostic significance: Most useful in diagnosing acute pancreatitis 
• amylase is also elevated in mumps, perforated ulcer, ruptured tubular pregnancy, pancreatic trauma 
• Most common usage for amylase test - trauma and pancreatitis
• lipase is used to detect or diagnose acute pancreatitis and pancreatic trauma
• CK-MB - major indicator for MI or secondary MI