Lec 1

• To initiate an immune response, the pathogen must breach the host's barriers
• Types of immunity

  • Innate
  • Adaptive
• Innate immunity


  • Quick, generic response
  • Recognizes there is a threat and attacks
• PRRs

  Pattern recognition receptors on cell surface to recognize pathogen
• Adaptive immunity


  • Very specific, recognizes exact strains
  • Memory response
  • Gets called in when innate can't deal with it alone
• Clonal selection


  Cells with right receptors are selected
• Innate and adaptive immunity


  Work together for a full immune response
• Cytokines

  Produced by innate immunity to stimulate and direct adaptive immunity
• Adaptive immunity consists of B lymphocytes (B cells) that produce antibodies to neutralize or mark pathogens, and T lymphocytes (T cells) that recognize infected host cells and destroy them through cell-mediated immunity.
• Tolerance


  Ensures that the immune system avoids destroying host tissue