Lymphoid System & Antibody Structure & Function

• The characteristic that applies to the variable domains of immunoglobulins is: they occur on both the H and L chains
• The statement about IgM immunoglobulins that is not true is: can cross placenta
• The number of antigen binding sites on a typical IgM immunoglobulin is: 10
• Bence-Jones proteins are identical to: L chains
• An Fab fragment consists of: 1 L chain & 1/2 an H chain
• The pairs that represent 2 different immunoglobulin allotypes is/are: IgG1m3 and IgG1m17
• L chains of antibody molecules are composed of: kappa
• The subclasses of IgG differ mainly in: arrangement of disulfide bonds
• The statement that best describes the role of the secretory component (SC) of IgA is: transport mechanism across endothelial cells
• The statement that best describes the main function of IgD is: enhancing proliferation of B cells
• The antibody class that is best at agglutination and complement fixation is: IgM
• The statement that can be attributed to the Clonal Selection Theory of antibody formation is: B cells are preprogrammed for specific antibody production
• The statement that is NOT TRUE regarding IgE immunoglobulin is: that IgE is heat stable
• If the results of serum protein electrophoresis show a significant decrease in the gamma band, a likely possible cause is: immunodeficiency disorder
• The organ that is considered the primary lymphoid organ is: thymus
• The type of cells that would be found in the primary follicle of a Lymph node is/are: undifferentiated B cells
• The statement that is TRUE about NK cells is: they recognize a lack of MHC proteins
• In the Thymus, positive selection of immature T cells is based upon recognition of: MHC antigens
• Undifferentiated lymphocytes originate in the: bone marrow
• Mature B cells are recognized by presence of: IgM and IgD
• Receptors on T cells that are responsible for rosetting with sheep red blood cells is/are: CD2
• The major portion of production of antibody occurs in: lymph nodes
• A distinguishing feature of a pre-B cell is: mu chains in the cytoplasm
• Genetic rearrangement for coding of light chains takes place: as cell becomes an immature B cell
• The unique surface marker/antigen found on the T cell subset known as helper/inducer is: CD4
• The surface markers that would represe3nt a Double Negative thymocyte is: CD2+, CD3-, CD4-, CD8-
• T-cell receptors for antigens is best described by: alpha & beta chains are unique for each antigen
• The variable domain on the antibody molecule is responsible for: forming antigen binding sites
• The structure of the IgM antibody is held together by: ""J" or joining chain
• The strongest bond forming between Antigen & Antibody results primarily from the: goodness of fit
• The strength of the bond between an antigen and antibody is called: avidity
• The specificity of an antigen for an antibody is determined by: epitopes
• The secondary immune response differs from the primary immune response: all of these occur in secondary response
• The organ responsible for the maturation and differentiation of T-lymphocytes is: thymus gland
• The identity of the immunoglobulin light chains are: kappa & lambda
• The component of the IgA antibody found only in the sIgA antibody is: secretory component (SC)
• The classes of immunoglobulins are distinguished by: distinct heavy chains
• The chemical composition of an antibody is: gamma globulines
• The cells that cooperate with B-cells to trigger antibody production are: T-lymphocytes
• The antibody found in highest concentration in the secondary immune response is: IgA