Enzyme inhabition

• Enzyme Inhibition


  Enzyme needs a way to be turned OFF when enough product is made
• Coligestion enzymes


  Stop working when no substrate is present. This is done by enzyme inhibitor.
• Enzyme inhibitors


  Can be a product of a metabolic pathway or a different molecule that has a similar shape to the substrate
• Types of enzyme inhibition

  • Competitive inhibition
  • Non-competitive inhibition
• Competitive inhibition


  • Similar shaped molecule bonds to the active site
• Non-competitive inhibition


  • A product from a metabolic pathway will bind to the ALLOSTERIC SITE on the active site
• Irreversible inhibitors


  • Lock into the active/allosteric sites of an enzyme, completely disabling the enzyme
• Irreversible inhibitors


  • Poisons like cyanide
  • Penicillin locking onto a cell wall enzyme in bacteria
• Reversible non-competitive inhibitors


  • Bind loosely to either the allosteric or active site
  • When the product is used up, it is taken from the allosteric site and the enzyme is turned ON