Competitive Binding

• GADDUM EQUATION = an extension of the Hill-Langmuir equation that describes competitive binding
• Ki = the equilibrium dissociation constant for a competing ligand. It's a measure of affinity and is equivalent to KD
• $pKi =$$-log(Ki)$
• $pKD =$$-log(KD)$
• COMPETITIVE BINDING EQUATION = used to plot competition binding to 50% of control
• IC50 = the concentration of...
• CHENG-PRUSOFF equation = an equation used to convert IC50 to Ki
• GADDUM EQUATION

  
• CHENG-PRUSOFF EQUATION