Macromolecular (Bulky) DNA adduct

• Formed by the transfer of aralkyl/ arylamine residue (from the carcinogen) --> to nucleotide --> formed DNA adduct
• Transfer aromatic/ multi-ringed compounds
• Chemical groups: PAH

  Example: Benzo[a]pyrene

  Structural change: N2 Guanine addict; N6 Adenine adduct
• Chemical groups: Mycotoxins

  Example: Aflatoxin B1

  Structural change: N7 Guanine adduct