rbc metabolism

• 7-8 um , average 7.2 um

  Erythrocytes Size
• Biconcave Disc


  Erythrocytes Shape
• 90-120 Days


  Erythrocytes Lifespan
• Erythrocytes Function


  Efficient transport of oxygen from the lungs to the tissues , and carbon dioxide from the tissues to the lungs
• Methemoglobin


  ferric state of blood
• Carboxyhemoglobin


  bound to carbon monoxide which has 210 times greater affinity
• Sulfhemoglobin


  exposure to sulfhydryl compounds
• Chocolate brown


  Methemoglobin color
• Cherry Red Allow


  Carboxyhemoglobin color
• Mauve - Lavender


  Sulfhemoglobin color
• plasma membrane


  RBCs have a very strong
• Central pallor


  indicates there is little to no hemoglobin in the area .
• periphery


  We can find hemoglobin in the _____ making it easier for OXYGEN to bind
• 140um²


  RED BLOOD CELL surface area
• 90fL


  RED BLOOD CELL volume
• RBC Membrane


  Function: To separate the intracellular fluid environment from the extracellular fluid environment
• RBC Membrane


  Allow nutrietn and ion passage selectively in and out of the cell
• RBC Membrane


  Allow the cell to deform when required
• 52 %


  Proteins %
• 40 %


  Lipids ( Phospholipids , Cholesterol ) %
• 8 %


  Carbohydrates %
• Helical configuration


  Alpha and beta spectrin
• Ankyrin


  bound to Band 3 protein
• Band 3


  anion exchanger
• Band 4.2


  Stabilizes the linkage of ankyrin to band 3
• Glycophorin C


  Transmembrane Gives RBC a negatively charged surface
• sialic acid


  Glycophorin C Contains
• SPECTRIN


  Cytoskeletal protein interacts w / other proteins
• cytoskeletal proteins


  Provides the shape / maintains the framework of the cell
• Yes


  Is Protein Interaction Important ?
• Hereditary spheocytosis


  occur if there is a problem in the spectrin protein
• spherical


  In px with Hereditary spherocytosis , the shape of their RBC - instead of biconcave , it becomes
• spherocyte


  The name of the cell if px has hereditary spherocytosis
• false


  true or false

  
  

  The spherocyte has CENTRAL PALLOR
• HEMOLYZE


  Cells that are spherocytic in shape tend to
• Aquaporin 1


  Water transporter
• Band 3 Anion Exchanger 1

  Anion transporter , support system for surface antigens of ABHblood group antigens
• Duffy blood group antigens

  Ca²+ transporter
• GLUTI


  Glucose transporter , supports ABH blood group antigens
• Glycophorin A


  Transports negatively charged sialic acid , supports MN blood group antigens