hgb

• HEMOGLOBIN


  Main cytoplasmic component of a mature RBC
• HEMOGLOBIN


  Conjugated CHON that gives red color to the RBC
• 1.34 mL


  1 g of Hemoglobin : _____ of OXYGEN
• 3.47 mg


  1 g of Hemoglobin : _____ of IRON ( Ferrous state )
• Methemoglobin ( Chocolate brown color )


  What happens if the Iron in the hemoglobin becomes Ferric ? →
• It can . But it DOES NOT release oxygen - it will only bind tightly to oxygen without releasing it


  What happens if the Iron in the hemoglobin becomes Ferric ?

  
  

  Can it bind with oxygen ?
• methemoglobinemia


  Individuals with _______ , they are cyanotic ; their tissues are hypoxic because they cannot release oxygen
• Hemoglobin


  carries oxygen from the lungs going to the tissues and from the tissues - it will take up carbon dioxide , bringing it to the lungs for exhalation .
• 2,3 - BPG


  the tissues , what should be present for hemoglobin to unload oxygen ?
• Peripheral Tissues


  Between the lungs and the peripheral tissues , which has higher concentration of 2,3 - BPG ?
• amino acids


  The globin is made up of
• globin


  a protein molecule ; it is made up of different amino acids
• E and F helicase

  The Heme group is bound to the
• 4 globin chains


  how many globin chains are seen in hgb?
• 1 hgb


  how many hemoglobin molecule carries 2 alpha and 2 non - alpha chains?
• 1


  Each globin molecule , is capable of how many heme group binding?
• 1 oxygen molecule


  Each globin molecule , 1 capable of heme group binding

  
  

  In each heme group , how many oxygen molecule?
• oxygen


  1 hemoglobin molecule can bind to 4 molecules of
• Helical


  Hemoglobin Molecule Conformity
• cleft pocket


  Globin chains loop to form a ______ for heme .
• What can you observe regarding the conformity of the globin chain ?

  It has a space in the center

  
  

  The space in the middle of the globin chain is where the heme group is located

  
  

  When globin coils , it forms a pocket
• Why do cleft pockets form ? Why is it not flat ?

  So that it will not lead to oxidation
• pocket cleft


  for iron to help retain it in a FERROUS STATE
• heme group


  Each globin chain contains a
• true


  true or false

  
  

  Each heme moiety can bind a single oxygen molecule
• false

  
  

  4 - o2 molecule


  true or false

  
  

  Each heme moiety can bind a single oxygen molecule

  
  

  therefore , a molecule of hemoglobin can transport up to 1 oxygen molecules .
• reversible


  The binding of oxygen to heme unit is
• WEAK reaction


  The interaction of FERROUS iron to the oxygen is a
• VERY STRONG


  ferric iron has a ______ interaction with oxygen
• REVERSIBLE


  Binding of oxygen to hemoglobin is
• FERROPROTOPORPHYRIN IX


  Heme is also known as
• ALPHA AND BETA


  majority of globin chains in an adult are
• Globin chains


  combination which will result to different hemoglobins
• Heme Globin


  COMPONENTS OF HEMOGLOBIN
• Heme


  Renders blood RED
• Heme


  Made up of PROTOPORPHYRIN IX and IRON
• Heme


  1 heme molecule = 1 oxygen molecule
• Globin


  Differs in polypeptide chains

  Adult : a and B
• true


  true or false

  
  

  
  

  4 globins in 1 hemoglobin molecule
• Chromosome 16


  Chromosomal Location

  Alpha Zeta