CT chemo drugs

• Sulfonamides

  1st clinical use in 1936
• Penicillin

  Mass production in 1941
• Trimethoprim Poisoning

  Leucovorin
• Dapsone overdose

  Methylene blue
• Dapsone


  Tx leprosy
• Toxic dose of dapsone

  50-300 mg/d
• Amantadine


  For parkinson dse
• Amantadine


  Cocaine Addiction
• Amantadine withdrawal

  Hyperthermia and Rigidity
• Tx for tachyarrythmias

  Beta-blocker (Propranolol and Esmolol)
• Dantrolene


  For neuroleptic malignant syndrome
• Amantadine


  Not effectively remove by dialysis
• Quinine


  Optical isomer of quinidine, tx for malaria, use as abortifacient, tx for nocturnal muscle cramps
• Retinal toxicity of quinine

  Ingestion after 9-10 hours
• Toxic dose of quinine in adults

  3-4 g
• Fatal dose of quinine in children

  1 g
• Quinine toxic dose

  Visual impairement- 10 mg/l
• Quinine toxic dose

  Blindness - 20 mg/l
• Quinine toxic dose

  Cardiac toxicity- 16 mg/l
• Tx for Quinine - cardiotoxicity

  IV bolus of Na bicarbonate 1-2 meq/kg
• Quinine induced blindnese

  Stellate ganglion blockers
• Chloroquinones and Aminoquinolones

  Prophylaxis for theraoy of malaria and parasitic dse
• Toxic dose of Chloroquine phosphate

  500 mg/week
• Chloroquinone

  Death in children - 300 mg
• Chloroquinone Lethal dose for adults

  30-50mg/kg
• Isozianid toxic dose

  1.5 g
• Severe toxic dose of isozianid

  80-150 mg/kg
• Isozianid


  For tuberculosis, causes hepatitits and chronic use
• Pyridoxine or vit b6


  Terminates diazepam-resistant seizure
• Mefloquine


  Causes hallucination, psychosis, seizure