Med org anti bacterial

• Antibacterial


  Substances produced by the microorganisms which has the capacity to inhibit the growth and cause destruction of other microorganisms
• Antibiotics


  Substances produced by the microorganisms which has the capacity to inhibit the growth and cause destruction of other microorganisms
• Organic Medicinal Chemistry


  Field of study
• Antibacterial agents


  Substances produced by the microorganisms which has the capacity to inhibit the growth and cause destruction of other microorganisms
• Bacteriostatic


  Inhibits the growth of bacteria
• Bactericidal


  Causes destruction of bacteria
• Cell wall synthesis inhibitors

  Antibacterial agents that inhibit the synthesis of the bacterial cell wall
• 1. lactams


  Class of antibacterial agents that contain a beta-lactam ring
• Glycopeptides


  Class of antibacterial agents that are glycosylated peptides
• Structure


  The chemical structure of an antibacterial agent
• Penicillins

  Class of beta-lactam antibiotics
• Penicillins


  • 6-aminopenicillamic acid
  • Beta-lactam ring
  • Thiazolidine ring
• PBP


  Penicillin-binding proteins, the target of penicillins
• Mechanism of action of penicillins

  Inhibit bacterial growth by interfering with the transpeptidation reaction of bacterial cell wall synthesis
• Cephalosporins


  Class of beta-lactam antibiotics
• Cephalosporins


  • 7-aminocephalosporanic acid
  • Beta-lactam ring
  • Dihydrothiazine ring
• Other beta-lactam drugs


  Antibacterial agents that contain a beta-lactam ring
• Carbapenems


  Class of beta-lactam antibiotics
• Carbapenems


  • Thienamycin (prototype)
  • Imipenem
  • Meropenem
  • Ertapenem
• Mechanism of action of carbapenems

  Inhibit dihydropeptidase
• Primaxine


  Combination of imipenem and cilastatin
• Monobactams


  Class of beta-lactam antibiotics
• Monobactams


  • Aztreonam
• Aztreonam


  "Magic Bullet" for Pseudomonas
• Protein synthesis inhibitors


  Antibacterial agents that inhibit bacterial protein synthesis
• Inhibitors of 30S


  Antibacterial agents that inhibit the 30S subunit of the bacterial ribosome
• Inhibitors of 50S


  Antibacterial agents that inhibit the 50S subunit of the bacterial ribosome
• Aminoglycosides


  Class of antibacterial agents that inhibit the 30S subunit of the bacterial ribosome
• Tetracycline


  Antibacterial agent that binds reversibly to the 30S subunit of the bacterial ribosome, blocking the binding of aminoacyl-tRNA
• Macrolides


  Class of antibacterial agents that inhibit the 50S subunit of the bacterial ribosome
• Macrolides


  • Erythromycin (from Streptomyces erythreus)
  • Clarithromycin (methylated erythromycin)
  • Azithromycin (unique pharmacokinetic property)
• Lincosamides


  Class of antibacterial agents that inhibit the 50S subunit of the bacterial ribosome
• Lincosamides


  • Lincomycin (from Streptomyces lincolnensis)
  • Clindamycin (potent agent against Bacteroides fragilis)
• Oxazolidinone


  Class of antibacterial agents that inhibit bacterial protein synthesis
• Streptogramin


  Class of antibacterial agents that inhibit the 50S subunit of the bacterial ribosome
• Streptogramin


  • Streptogramin A
  • Streptogramin B
• Chloramphenicol


  Unclassified antibiotic that inhibits bacterial protein synthesis
• Tetracyclines were originally isolated from Streptomyces bacteria.
• Penicillin is the first antibiotic discovered by Alexander Fleming
• Beta lactamase inhibitors

  Inactives beta lactamse