IMHM MIDTERM OTHER MAJOR BLOOD GROUP

• Saline phase /@4C


  Anti-P1 reacts at
• Saline phase /@4C


  Anti-I reacts at
• a4°C


  Anti-i reacts at
• Saline phase


  Anti-M reacts at
• Saline / immediate spin phase


  Anti-N reacts at
• 37°C/AHG


  Anti-Ss reacts at
• AHG/37C


  Anti-K reacts at
• AHG/37C


  Anti-Fya/Fyb reacts at
• Saline -phase (crossmatching)


  Anti-Lua reacts at
• 37°C/AHG


  Anti-Lub reacts at
• Lewis


  blod group produced by tissues cells
• Legene


  Produce lewis antigen
• FUT3


  codes for the production fo fucosyl transferase
• Pancrease, Stomach, Intestine, Skeletal muscle, adrenal gland


  organs that produce lewis ag
• i MNSs U Kidd Kell Duffy


  antigens that are well developed at birth
• P I Lewis Lutheran


  Antigens that are poorly developed at birth
• Le(a-,b+)


  if both the Le and Se genes are expressed in the rbc membrane, what is the expression of the gene
• Le(a+,b-)


  If only the Le gene is expressed, no Se gene in the rbc membrane, what is the expression of the gene?
• Le(a-,b-)


  If both Le and Se genese are not expressed, then the gene expression will be
• Le(a-,b-)


  If the Se gene is the only one expressed, then the gene expression will be
• Lea


  Most common Lewis antigen
• Leb ag


  receptor antigen for H. pylori (causative agent for peptic ulcer)
• Lex ag


  marker for hodgkins Lymphoma (Reed sternberg cell)
• P, P1, Pk


  what are the 3 antigens of P system
• glycosyltransferase


  P P1 PK are produced by what enzyme
• chromosome 22, 6, 1


  P

  Ii

  Duffy blood group is located in
• cancer, alcohol cirrhosis, viral and parasitic infection


  3 conditions of Le (a-, b-)
• P antigen


  it is the receptor for Parvovirus B19
• Donath-Landsteiner test


  Test of choice for biphasic hemolysin
• anti-PP1Pk (anti-Tja)


  It is associated with spontaneous abortion in early pregnancy
• Papain and Ficin


  enhances the aftivity of I antigen
• Adult-cell , children-cell


  Big I demonstrate strong reaction in _, while small i in _
• M. pneumoniae, L. monocytogenes


  Has I like antigens on their surface (give 2)
• Associated with EBV (infectious mononucleosis), Liver cirrhosis, Myeloid Leukemia, Reticulosis
• MNS blood group


  the gene responsible for production of glycosyltransferase (chromosome 4)
• MN = Landsteiner-Levine, Ss = Walsh-Montgonery


  Discovered

  MN and Ss
• MN ag


  Cord cell is rich in what antigens
• MN ag


  this ag is important for paternity testing
• position 1 and 5


  only difference of the 2 amino acid
• serine-glycine, leucine-glutamic-acid


  position of M ag _ & _

  N ag _ & _