DNA_virus pt. 1

• Smallest of the DNA viruses

  Parvoviridae
• 1. Dependovirus (adeno-associated viruses)
  2. Parvovirus (animal virus)
  3. Erythrovirus
  4. Bocavirus


  4 Genus of Parvoviridae
• Wide distribution in warm blooded animals; Naked icosahedral ssDNA virus

  Parvoviridae
• The viral genome contains a single-stranded DNA measuring 4000–6000 bases in length (4-6 kb)

  Parvovirus B-19
• High Resistant to inactivation

  Parvovirus B-19
• The viruses withstand heating at 56°C for 30 minutes

  Parvovirus B-19
• Stable at pH 3 and pH 9

  Parvovirus B-19
• Formalin, beta propiolactone, and oxidizing agents

  Parvovirus B-19
• Progenitor Erythroid Cell

  target cell of Parvovirus B-19
• it causes Fifth Disease - Parvovirus B - 19
• Fifth Disease (Erythema infectiosum) - Parvovirus B-19
• Arthralgia and Arthritis (Adult) - Parvovirus B-19
• Arthralgia and Arthritis (Adult) - Parvovirus B-19
• Aplastic Crisis (CHA) - Parvovirus B-19
• 1st stage of Fifth Disease - Fever, Malaise, headache (infectious stage)
• 2nd Stage of Fifth disease - Rashes (healing stage)
• infectious stage of fifth disease - 1st stage
• healing stage of fifth disease - 2nd stage
• First isolated in 2005 in upper respiratory secretions of acutely ill children in Sweden

  Human Bocavirus 1
• Highest infection during winter - HBoV
• Target cell is the Epithelial cell of the respiratory tract - HBoV
• URT and LRT illnesses including cough, rhinorrhea, fever, difficulty breathing, diarrhea, conjunctivitis, and rash - HBoV
• does not code for polymerases - Papovaviridae
• meaning of Papovaviridae

  1. Papillomavirus
  2. Polyomavirus
  3. Vacuolating virus
• The common cause of Genital Warts - HPV
• 2nd Leading cause of cancer in women - HPV
• Exhibit Tissue Tropism - HPV
• Plantar warts - HPV 1, 2, 4
• Common Skin warts - HPV 1, 2, 4, 7, 26, 29
• Flat warts - HPV- 3, 10, 27, 28, 41
• Epidermodysplasia Verruciformis - HPV - 5, 8, 9, 14, 15, 17, 19, 20, 21-25, 36, 38, 46
• Genital warts - HPV - 6, 11
• Cervical and Penile Cancer - HPV- 16, 18, 45
• Laryngeal papilloma - HPV-6, 11
• Oral Papilloma - HPV 2, 6, 11, 16
• Conjuctival Papilloma - HPV - 11
• Keratoacanthoma - HPV - 37
• Koilocytes - enlarged keratinocytes with clear haloes around shrunken nuclei
• uses vinegar solution and pap smear for laboratory diagnosis - HPV
• Gardasil vaccination - HPV - 6, 11, 16, 18