TROPANE(SOLANACEOUS GROUP)

• Belladonna Leaf

  ▪ Aka Deadly Nightshade Leaf or Belladonna Herb

  ▪ Dried leaf and flowering or fruiting top

  ▪ Atropa belladonna, Solanaceae

  ▪ Atropos – means inflexible, name of Greek Fate

  that cuts the thread of life

  Constituent/s

  ▪ Hyoscyamine and atropine

  Use/s

  ▪ Antimuscarinic and spasmolytic properties -

  adjunct in treatment of peptic ulcer; functional

  digestive disorder

  ▪ Anticholinergic property – controls excess motor

  activity of GIT and spasm of urinary tract
• Hyoscyamus

  ▪ Aka Henbane

  ▪ Hyoscyamus niger

  ▪ Toxic to swine

  Constituents

  ▪ Hyoscamine

  ▪ Atropine

  ▪ Scopolamine aka hyoscine
• Stramonium

  ▪ Datura Stramonium aka Jimson

  Weed; Jamestown Weed

  ▪ Datura metel aka Talumpunay or

  Thorn Apple

  Use/s

  ▪ Treatment of asthma (inhaling the

  vapor)
• Mandragora

  ▪ Aka European Mandrake

  ▪ Mandragora officinarum

  Use/s

  ▪ Folkloric uses - The root

  is hallucinogenic and narcotic. In

  sufficient quantities, it induces a state

  of unconsciousness and was used as

  an anaesthetic for surgery in ancient

  times.
• Coca

  ▪ Aka Coca

  ▪ Erythroxylum coca, Erythroxylaceae

  Use/s

  ▪ Psychomotor stimulant with a strong

  abuse potential

  ▪ Vasoconstrictor
• Scopolamine

  ▪ Present in Hyoscyamus niger

  ▪ Has depressant activity on CNS

  ▪ Treatment of motion sickness

  ▪ Employed for preanesthetic

  sedation and obstetric amnesia in

  conjunction with analgesics

  ▪ Available as Trans-scoop or

  transderm scop – 4 hours before;

  anti-emetic effect
• Atropine

  ▪ Anticholinergic

  ▪ Antispasmodic

  ▪ Antisialagogue

  ▪ Mydriatic and cycloplegic

  antidote for cholinesterase

  inhibitors such as physostigmine

  and organophosphate

  insecticides
• Hyoscyamine

  ▪ When extracted from the plant, it is

  usually racemized during the process and

  converted into atropine

  ▪ Its salt, Hyoscyamine sulfate is

  extremely poisonous

  ▪ Anticholinergic – aids in the control of

  gastric secretion, visceral spasm,

  hypermotility and associated abdominal

  cramps

  ▪ Used in parkinsonism – to reduce

  rigidity, tremors; control sialorrhea and

  hyperhidrosis