PYRIDINE-PIPERIDINE

• Tobacco Plant

  ▪ Dried Leaves

  ▪ Nicotiana tabacum, Solanaceae

  ▪ Nicotiana was named after a French diplomat, Jane

  Nicot.

  Constituent/s:

  ▪ Nicotine (Colorless to pale yellow, hygroscopic,

  volatile liquid)

  Use/s:

  ▪ Ganglionic (nicotinic) cholinergic receptor agonist

  ▪ Smoking deterrent

  ▪ Available in transdermal systems and chewing gum

  base
• Areca

  ▪ Aka Betel Nut, Areca Nut

  ▪ Dried rape seed

  ▪ Areca catechu, Arecaceae

  Constituent/s and uses/effects:

  ▪ Arecoline (aka Arecaidine methyl ester) – anthelminthic in

  veterinary practice; vermicide; taeniafuge; most

  abundant

  ▪ Arecaidine (aka N-methyl guvacine)

  ▪ Guvacine (aka Tetrahydronicotinic acid)

  ▪ Guvacoline ( aka Guvacine methyl ester)

  ▪ Tannin – the type of tannin present causes esophageal

  cancer

  Areca + Lime + leaves of Piper betel + gambir → this mixture

  is known as “punsupari”, a stimulant masticatory in India
• Lobelia

  ▪ Aka Indian Tobacco

  ▪ Dried leaves and tops

  ▪ Lobelia inflata, Lobeliaceae

  ▪ Lobelia named in honor of Flemish botanist, Matthias

  de L’Obel

  Constituent/s and uses/effects:

  ▪ Lobeline or alpha lobeline (colorless crystals)

  ▪ Smoking deterrent (since it produces similar, weaker,

  pharmacologic effects to nicotine:

  o Formerly incorporated in tablets and lozenges

  o Controlled studies showed that it has only a

  placebo effect so products were removed from

  the market