Amphetamine drugs are dopamine antagonists which means that they stimulate neurons containing dopamine causing the synapse to be flooded with this neurotransmitter. It has been found that large doses of these drugs cause hallucinations and delusions similar to the symptoms seen in schizophrenia.
a strength of of the dopamine hypothesis is that it has practical applications

Typical antipsychotic drugs used to treat schizophrenia are all dopamine antagonists. they work by reducing stimulation of neurons containing dopamine by blocking D2 receptors and so reduces positive symptoms like hallucinations and delusions. this is a positive as it shows the dopamine hypothesis is useful in developing treatments that benefit lives but also explains that reducing dopamine reduces symptoms
Evaluation point showing serotonin also plays a role in SZ
Newer antipsychotic drugs called atypical antipsychotics only temporarily block dopamine receptors whilst also acting on serotonin receptors and these drugs have been shown to be more effective than the typical antipsychotics in reducing SZ symptoms. This seems to suggest that serotonin also plays a role in SZ and the fact this is not considered by dopamine hypothesis suggests the explanation may be limited.
