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SP 128
SP 128: 3rd LE
[22] Neurodegenerative Conditions
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Created by
Amanda
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Cards (14)
Motor Neuron disease
atrophy
of neurons in
precentral gyrus
frontal lobe
/
ventral lobe
of
spinal cord
MND
mean disease:
3 years
prolongs by:
3 month
associated in
FTD
TDP-43
commonly found in
surviving motor neurons
pathological
cause of
FTD
Amyotrophic Lateral Sclerosis
lateral
and
anterior columns
of the spinal cord
demyelination
of axons
TDP-43
:
C9orf43
Sporadic
and
hereditary
55-75
years old
men
>
women
caucasians
and
non-Hispanics
Manifestation of ALS
muscle
weakness
&
atrophy
fasciculation
(twitching)
distal to
proximal
;
limbs
first
Swallowing Difficulties of ALS in Oral Prep
saliva
chewing
food
drooling
residue
in
mouth
food
spilling
outside
mouth
Swallowing Difficulties of ALS in Preparatory Stage
food
sticks in
throat
coughing
/
choking
shortness
of
breath
spilling
through
nose
Swallowing Difficulties of ALS in Esophageal Stage
food stick
in
throat
and
back
of the
neck
regurgitation
direct
pathways inhibits
IGP
indirect
pathways inhibits
EGP
, prevent
subthalamic nucleus
, activates
IGP
dopamine
encourages
direct
, and
inhibits indirect
acetylcholine
encourage
indirect
, and
inhibits direct
Parkinson's
Disease
common movement disorder
loss of
dopamine
in
substantia nigra
mean duration:
12.4
years
PD Etiology
multifactorial
disease
mean onset:
60
% years old
sporadic
10-15%
genetic
alpha-synuclein
protein found in
40
%
Lewy body dementia
PD Speech and Swallowing Difficulties
dysphonia
;
aphonia
hypokinetic dysarthria
swallowing
cognitive dysfunction:
heterogenous
PD Specific Speech Intervention
LSVT
:
Lee Silverman Voice Treatment