developing new medicines

• Microorganisms and plants have been evolving for millions of years and along the way they've evolved to produce a range of substances that are able to do all sorts of things including killing pathogens
• Instead of having to develop all of our drugs from scratch we've been able to take these substances from them and either use them directly as medicines or sometimes modify them in a lab of it first and then use them as medicines
• Substances taken from nature and used as medicines

  • Aspirin (from willow tree bark)
  • Digitalis (from foxglove plants)
  • Penicillin (from Penicillium fungus)
• Efficacy


  How well the drug works, e.g. how good is an antibiotic at killing bacteria or how well does a pain relief medication reduce your pain
• Toxicity

  How harmful the drug is, e.g. does it damage our cells or have any side effects
• Dosage


  How much of the drug or what concentration of the drug should be given
• Drug testing stages


  1. Testing on human cells and tissues

  2. Testing on live animals

  3. Clinical testing on healthy volunteers

  4. Clinical testing on people with the target illness
• Clinical trials should be blind and use a placebo
• Blind trial


  Neither the doctors nor the volunteers know which drugs have been taken by whom until all the results have been analyzed
• Double-blind trial


  Neither the doctors nor the volunteers know which drugs have been taken by whom until all the results have been analyzed
• Peer-review is central to science and helps to prevent false claims or results from getting published