In 1569, after they heard of Norfolk's arrest, (and with the encouragement of their wives, Jane Neville and Ann Percy) the Catholics Earls rebelled. They wanted to restore the Catholic religion and so took control of Durham and destroyed ev idence of Protestantism before beginning to march South with an army of 4,500 men (many of these loyal supporters of the Earls).
However, Elizabeth raised an army of 14,000 men and when the royal army arrived, the rebels, whose Spanish support had never arrived, were easily defeated. Westmoreland escaped, but Northumberland was imprisoned and about 450 rebels were executed and Mary, Queen of Scots remained in prison for the next 14 years.